Article
The evolutionary landscape of alternative splicing in vertebrate species.
Science (New York, N.Y.) - 21 Dec 2012
Barbosa-Morais Nuno L, Irimia Manuel, Pan Qun, Xiong Hui Y, Gueroussov Serge, Lee Leo J, Slobodeniuc Valentina, Kutter Claudia, Watt Stephen, Colak Recep, Kim TaeHyung, Misquitta-Ali Christine M, Wilson Michael D, Kim Philip M, Odom Duncan T, Frey Brendan J, Blencowe Benjamin J
Abstract excerpt
How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of...
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