Article
Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation.
Molecular systems biology - 1 Apr 2020
Li Yisheng, Schaefke Bernhard, Zou Xudong, Zhang Min, Heyd Florian, Sun Wei, Zhang Bin, Li Guipeng, Liang Weizheng, He Yuhao, Zhou Juexiao, Li Yunfei, Fang Liang, Hu Yuhui, Chen Wei
Abstract excerpt
Alternative polyadenylation (APA) is a major layer of gene regulation. However, it has recently been argued that most APA represents molecular noise. To clarify their functional relevance and evolution, we quantified allele-specific APA patterns in multiple tissues from an F1 hybrid mouse. We found a clearly negative correlation between gene expression and APA diversity for the 2,866 genes (24.9%) with a dominant...
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