Article
The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice.
Biology of reproduction - 1 Nov 2015
Brinkmeier Michelle L, Geister Krista A, Jones Morgan, Waqas Meriam, Maillard Ivan, Camper Sally A
Abstract excerpt
Chromatin remodeling influences gene expression in developing and adult organisms. Active and repressive marks of histone methylation dictate the embryonic expression boundaries of developmentally regulated genes, including the Hox gene cluster. Drosophila ash1 (absent, small or homeotic discs 1) gene encodes a histone methyltransferase essential for regulation of Hox gene expression that interacts genetically...
Topics
- Alleles
- Animals
- DNA-Binding Proteins
- Epididymis
- Female
- Fertility
- Genes, Homeobox
- Histone-Lysine N-Methyltransferase
- Homeodomain Proteins
- Male
- Mice, Inbred C57BL
- Transcription Factors
- Uterus