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Article

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.

Blood - 9 Feb 2012

Nijnik Anastasia, Clare Simon, Hale Christine, Raisen Claire, McIntyre Rebecca E, Yusa Kosuke, Everitt Aaron R, Mottram Lynda, Podrini Christine, Lucas Mark, Estabel Jeanne, Goulding David, Adams Niels, Ramirez-Solis Ramiro, White Jacqui K, Adams David J, Hancock Robert E W, Dougan Gordon

Abstract excerpt

Stem cell differentiation and lineage specification depend on coordinated programs of gene expression, but our knowledge of the chromatin-modifying factors regulating these events remains incomplete. Ubiquitination of histone H2A (H2A-K119u) is a common chromatin modification associated with gene silencing, and controlled by the ubiquitin-ligase polycomb repressor complex 1 (PRC1) and H2A-deubiquitinating enzymes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22184403
DOI: 10.1182/blood-2011-05-352666

Genes

PRC1

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The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.PMID 22184403Read ↗

Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.Semantic proximity Read ↗

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