Article
High-density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin-1.
British journal of pharmacology - 1 Feb 2016
Lee Man K S, Moore Xiao-Lei, Fu Yi, Al-Sharea Annas, Dragoljevic Dragana, Fernandez-Rojo Manuel A, Parton Robert, Sviridov Dmitri, Murphy Andrew J, Chin-Dusting Jaye P F
Abstract excerpt
BACKGROUND AND PURPOSE: Monocyte-derived macrophages are critical in the development of atherosclerosis and can adopt a wide range of functional phenotypes depending on their surrounding milieu. High-density lipoproteins (HDLs) have many cardio-protective properties including potent anti-inflammatory effects. We investigated the effects of HDL on human macrophage phenotype and the mechanisms by which these occur....
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