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Article

Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.

The Journal of biological chemistry - 26 Feb 2010

Ohashi Koji, Parker Jennifer L, Ouchi Noriyuki, Higuchi Akiko, Vita Joseph A, Gokce Noyan, Pedersen Anette Amstrup, Kalthoff Christoph, Tullin Søren, Sams Anette, Summer Ross, Walsh Kenneth

Abstract excerpt

It is established that the adipocyte-derived cytokine adiponectin protects against cardiovascular and metabolic diseases, but the effect of this adipokine on macrophage polarization, an important mediator of disease progression, has never been assessed. We hypothesized that adiponectin modulates macrophage polarization from that resembling a classically activated M1 phenotype to that resembling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20028977
DOI: 10.1074/jbc.M109.088708
PMCID: PMC2825410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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