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Article

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.

Circulation - 24 Feb 2009

Kao W H Linda, Arking Dan E, Post Wendy, Rea Thomas D, Sotoodehnia Nona, Prineas Ronald J, Bishe Bryan, Doan Betty Q, Boerwinkle Eric, Psaty Bruce M, Tomaselli Gordon F, Coresh Josef, Siscovick David S, Marbán Eduardo, Spooner Peter M, Burke Gregory L, Chakravarti Aravinda

Abstract excerpt

BACKGROUND: The ECG QT interval is associated with risk of sudden cardiac death (SCD). A previous genome-wide association study demonstrated that allelic variants (rs10494366 and rs4657139) in the nitric oxide synthase 1 adaptor protein (NOS1AP), which encodes a carboxy-terminal PDZ ligand of neuronal nitric oxide synthase, are associated with the QT interval in white adults. The present analysis was conducted to...

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Share to Adaptor Proteins, Signal Transducing
Share to Aged
Share to Death, Sudden, Cardiac
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Share to Polymorphism, Single Nucleotide
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Source

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Identifiers

PMID: 19204306
DOI: 10.1161/CIRCULATIONAHA.108.791723
PMCID: PMC2782762

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.PMID 19204306Read ↗

Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.Semantic proximity Read ↗

Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).Semantic proximity Read ↗

A common NOS1AP genetic polymorphism, rs12567209 G>A, is associated with sudden cardiac death in patients with chronic heart failure in the Chinese Han population.Semantic proximity Read ↗

Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population.Semantic proximity Read ↗

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.Semantic proximity Read ↗

NOS1AP Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.Semantic proximity Read ↗

Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death.Semantic proximity Read ↗

Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

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