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Article

Specific blockade CD73 alters the "exhausted" phenotype of T cells in head and neck squamous cell carcinoma.

International journal of cancer - 15 Sept 2018

Deng Wei-Wei, Li Yi-Cun, Ma Si-Rui, Mao Liang, Yu Guang-Tao, Bu Lin-Lin, Kulkarni Ashok B, Zhang Wen-Feng, Sun Zhi-Jun

Abstract excerpt

The adenosine-induced immunosuppression hampers the immune response toward tumor cells and facilitates the tumor cells to evade immunosurveillance. CD73, an ecto-5-nucleotidase, is the ectoenzyme dephosphorylating extracellular AMP to adenosine. Here, using immunocompetent transgenic head and neck squamous cell carcinoma (HNSCC) mouse model, immune profiling showed high expression of CD73 on CD4+ and CD8+ T cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GPI-Linked Proteins

Share to Head and Neck Neoplasms

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Share to Lymphocytes, Tumor-Infiltrating

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Share to Receptor, Transforming Growth Factor-beta Type I

Source

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Identifiers

PMID: 29663369
DOI: 10.1002/ijc.31534
PMCID: PMC11523565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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