Article
IDH1 mutation activates mTOR signaling pathway, promotes cell proliferation and invasion in glioma cells.
Molecular biology reports - 1 Oct 2022
Avsar Timucin, Kose Tansu Bilge, Oksal Muhammed Deniz, Turan Gizem, Kilic Turker
Abstract excerpt
BACKGROUND: Glioma is the most common type of brain tumors and isocitrate dehydrogenase (IDH1) gene is the most prominent molecular marker about the disease prognosis, response to therapy and patient survival. There are conflicting data about the effect of IDH1 mutation on glial cell proliferation, invasion and migration characteristics. The effect of IDH1 mutation on mTOR signaling pathway, which has key roles...
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