Article
Amplification refractory mutation system polymerase chain reaction versus optimized polymerase chain reaction restriction-fragment length polymorphism for apolipoprotein E genotyping of majorly depressed patients.
Molecular medicine reports - 1 Nov 2015
You Hongmin, Chen Jin, Zhou Jingjing, Huang Hua, Pan Junxi, Wang Ziye, Lv Lin, Zhang Lujun, Li Juan, Qin Bin, Yang Yongtao, Xie Peng
Abstract excerpt
Major depressive disorder (MDD) is a prevalent, debilitating mood disorder that has been associated with several genetic polymorphisms. One such polymorphism, namely that of apolipoprotein E (APOE), has three allelic forms (ε2, ε3 and ε4) that encode for six unique isoforms of the APOE protein. A growing number of techniques have been developed for APOE genotyping; however, not all polymerase chain reaction...
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