Article

Hif-1a-Mediated Disruption of Cellular Junctions: The Impact of Hypoxia on the Tumor Microenvironment and Invasion

2025-05-05

Abstract excerpt

Hypoxia is a critical factor driving cellular adaptation, reshaping the tumor microenvironment (TME) through genetic, metabolic, and structural changes that promote tumor survival and proliferation. Hypoxia-inducible factor-1α (HIF-1a) plays a central role in this process by regulating angiogenesis, metabolic reprogramming, and immune evasion through numerous pathways, ultimately enabling tumor cells to survive, i...

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Literature Corpus work: 28bbb628-a1a5-56e1-bb7f-e41b6bb9fecd
DOI: 10.20944/preprints202505.0189.v1

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