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Article

Hormonal carcinogenesis

1 Mar 2000

Abstract excerpt

Hormone-related cancers, namely breast, endometrium, ovary, prostate, testis, thyroid and osteosarcoma, share a unique mechanism of carcinogenesis. Endogenous and exogenous hormones drive cell proliferation, and thus the opportunity for the accumulation of random genetic errors. The emergence of a malignant phenotype depends on a series of somatic mutations that occur during cell division, but the specific genes...

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PMID: 10688862
DOI: 10.1093/carcin/21.3.427

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