Article
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.
Cancer cell - 14 Sept 2015
Churchman Michelle L, Low Jonathan, Qu Chunxu, Paietta Elisabeth M, Kasper Lawryn H, Chang Yunchao, Payne-Turner Debbie, Althoff Mark J, Song Guangchun, Chen Shann-Ching, Ma Jing, Rusch Michael, McGoldrick Dan, Edmonson Michael, Gupta Pankaj, Wang Yong-Dong, Caufield William, Freeman Burgess, Li Lie, Panetta John C, Baker Sharyn, Yang Yung-Li, Roberts Kathryn G, McCastlain Kelly, Iacobucci Ilaria, Peters Jennifer L, Centonze Victoria E, Notta Faiyaz, Dobson Stephanie M, Zandi Sasan, Dick John E, Janke Laura, Peng Junmin, Kodali Kiran, Pagala Vishwajeeth, Min Jaeki, Mayasundari Anand, Williams Richard T, Willman Cheryl L, Rowe Jacob, Luger Selina, Dickins Ross A, Guy R Kiplin, Chen Taosheng, Mullighan Charles G
Abstract excerpt
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here, we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations synergistically promote the development of an aggressive lymphoid leukemia. Ikzf1 alterations result in acquisition...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.