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Article

BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.

Nature - 1 May 2008

Mullighan Charles G, Miller Christopher B, Radtke Ina, Phillips Letha A, Dalton James, Ma Jing, White Deborah, Hughes Timothy P, Le Beau Michelle M, Pui Ching-Hon, Relling Mary V, Shurtleff Sheila A, Downing James R

Abstract excerpt

The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leukaemia samples from 304 individuals with ALL, including 43 BCR-ABL1 B-progenitor ALLs and 23 CML...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 18408710
DOI: 10.1038/nature06866

Genes

ABL1
BCR
IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.PMID 18408710Read ↗

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALLSemantic proximity Read ↗

IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Genetic abnormalities associated with acute lymphoblastic leukemia.Semantic proximity Read ↗

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report.Semantic proximity Read ↗

IKZF1 alterations in acute lymphoblastic leukemia: The good, the bad and the ugly.Semantic proximity Read ↗

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcomeSemantic proximity Read ↗

Ikaros and leukaemia.Semantic proximity Read ↗

Ikaros and Tumor Suppression in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

IKAROS Gene Deleted B-Cell Acute Lymphoblastic Leukemia in Mexican Mestizos: Observations in Seven Patients and a Short Review of the LiteratureSemantic proximity Read ↗

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistanceSemantic proximity Read ↗

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).Semantic proximity Read ↗

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