Article
Comparison of Major and Minor Viral SNPs Identified through Single Template Sequencing and Pyrosequencing in Acute HIV-1 Infection.
PloS one - 1 Jan 2015
Iyer Shyamala, Casey Eleanor, Bouzek Heather, Kim Moon, Deng Wenjie, Larsen Brendan B, Zhao Hong, Bumgarner Roger E, Rolland Morgane, Mullins James I
Abstract excerpt
Massively parallel sequencing (MPS) technologies, such as 454-pyrosequencing, allow for the identification of variants in sequence populations at lower levels than consensus sequencing and most single-template Sanger sequencing experiments. We sought to determine if the greater depth of population sampling attainable using MPS technology would allow detection of minor variants in HIV founder virus populations...
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