Article
MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals.
Viruses - 16 Jul 2020
Stunnenberg Melissa, van Pul Lisa, Sprokholt Joris K, van Dort Karel A, Gringhuis Sonja I, Geijtenbeek Teunis B H, Kootstra Neeltje A
Abstract excerpt
The mitochondrial antiviral protein MAVS is a key player in the induction of antiviral responses; however, human immunodeficiency virus 1 (HIV-1) is able to suppress these responses. Two linked single nucleotide polymorphisms (SNPs) in the MAVS gene render MAVS insensitive to HIV-1-dependent suppression, and have been shown to be associated with a lower viral load at set point and delayed increase of viral load...
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