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Article

In-depth characterization of viral isolates from plasma and cells compared with plasma circulating quasispecies in early HIV-1 infection.

PloS one - 1 Jan 2012

Dalmau Judith, Codoñer Francisco M, Erkizia Itziar, Pino Maria, Pou Christian, Paredes Roger, Clotet Bonaventura, Martinez-Picado Javier, Prado Julia G

Abstract excerpt

BACKGROUND: The use of in vitro models to unravel the phenotypic characteristics of circulating viral variants is key to understanding HIV-1 pathogenesis but limited by the availability of primary viral isolates from biological samples. However, overall in vivo genetic variability of HIV-1 within a subject may not be reflected in the viable viral population obtained after isolation. Although several studies have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

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Share to RNA, Viral

Share to Sequence Analysis, DNA

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Identifiers

PMID: 22393441
DOI: 10.1371/journal.pone.0032714
PMCID: PMC3290612

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