Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study.

doi:10.1177/0271678X17707397

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Article

Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Feb 2018

Rojas Santiago, Brugulat-Serrat Anna, Bargalló Nuria, Minguillón Carolina, Tucholka Alan, Falcon Carles, Carvalho Andreia, Morán Sebastian, Esteller Manel, Gramunt Nina, Fauria Karine, Camí Jordi, Molinuevo José L, Gispert Juan D

Abstract excerpt

Cerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's disease. The ɛ4 allele of the APOE gene is the major factor accountable for Alzheimer's disease heritability. However, the relationship between white matter hyperintensities and APOE genotype in healthy subjects remains controversial. We investigated the...

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PMID: 28492093
DOI: 10.1177/0271678X17707397
PMCID: PMC5951016

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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