Article
A 17q12 allele is associated with altered NK cell subsets and function.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2012
Xia Zongqi, Liu Qingquan, Berger Christoph T, Keenan Brendan T, Kaliszewska Anna, Cheney Patrick C, Srivastava Gyan P, Castillo Irene Wood, De Jager Philip L, Alter Galit
Abstract excerpt
NK cells play an important role in innate immunity. A previous genome-wide association study demonstrated an association between a 17q12 allele (rs9916629(C)) and lower frequency of CD3(-)CD56(+) NK cells in peripheral blood. We performed an analysis that not only replicates the original result of the genome-wide association study (p = 0.036) but also defines the specific cell subpopulations and functions that...
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