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ICA1L forms BAR-domain complexes with PICK1 and is critical for acrosome formation in spermiogenesis

1 Jan 2015

Abstract excerpt

Mutations in the Pick1 gene cause globozoospermia, a male infertility disorder, in both mice and humans. PICK1 is crucial for vesicle trafficking, and its deficiency in sperm cells leads to abnormal vesicle trafficking from the Golgi to the acrosome. This eventually disrupts acrosome formation and leads to male infertility. Here, we identified ICA1L, which has sequence similarities to ICA69 (also known as ICA1),...

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PMID: 26306493
DOI: 10.1242/jcs.173534

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