Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance

23 Apr 2013

Abstract excerpt

Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here, we identify the lipid binding BAR (Bin/amphiphysin/Rvs) domain protein PICK1 (protein interacting with C kinase 1) as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Erythrocyte Function and Pathophysiology
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23630454
DOI: 10.1371/journal.pbio.1001542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose TolerancePMID 23630454Read ↗

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesisSemantic proximity Read ↗

Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cellsSemantic proximity Read ↗

ICA1L forms BAR-domain complexes with PICK1 and is critical for acrosome formation in spermiogenesisSemantic proximity Read ↗

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.Semantic proximity Read ↗

The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis.Semantic proximity Read ↗

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.Semantic proximity Read ↗

Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.Semantic proximity Read ↗

ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance.Semantic proximity Read ↗

BBSome: An essential component of hypothalamic regulation of energy homeostasisSemantic proximity Read ↗

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.Semantic proximity Read ↗

Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila.Semantic proximity Read ↗

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.