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CCDC189 affects sperm flagellum formation by interacting with CABCOCO1

25 Jun 2023

Abstract excerpt

ABSTRACT Multiple morphological abnormalities of the sperm flagella (MMAF) are one of the major causes of male infertility and are characterized by multiple defects. In this study, we found that the coiled-coil domain-containing 189 (Ccdc189) gene was predominantly expressed in mouse testes and that inactivation of the Ccdc189 gene caused male infertility. Histological studies revealed that most sperm from...

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PMID: 37601242
DOI: 10.1093/nsr/nwad181

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