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Article

PICK1 deficiency causes male infertility in mice by disrupting acrosome formation

2 Mar 2009

Abstract excerpt

Protein interacting with C kinase 1 (PICK1) is a peripheral membrane protein involved in protein trafficking, a function that has been well characterized in neurons. Here, we report that male mice deficient in PICK1 are infertile and have a phenotype resembling the human disease globozoospermia. The primary defect in the testes of Pick1-knockout mice was fragmentation of acrosomes in the early stages of...

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PMID: 19258705
DOI: 10.1172/jci36230

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PICK1 deficiency causes male infertility in mice by disrupting acrosome formationPMID 19258705Read ↗

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