Article
Experimental and molecular support for Cfap70 as a causative gene of 'multiple morphological abnormalities of the flagella' with male infertility†.
Biology of reproduction - 13 Oct 2023
Chen Jingwen, Wang Yaling, Wu Bangguo, Shi Huijuan, Wang Lingbo
Abstract excerpt
Multiple morphological abnormalities of the flagella, a severe form of asthenozoospermia, can lead to male infertility. Recent studies have implicated an association between human CFAP70 deficiency and multiple morphological abnormalities of the flagella; however, the underlying biological mechanism and supporting experimental evidence in animal models remain unclear. To address this gap, we used CRISPR/Cas9...
Topics
- Male
- Animals
- Humans
- Mice
- Mutation
- Semen
- Flagella
- Infertility, Male
- Sperm Tail
- Spermatozoa
- A Kinase Anchor Proteins