Article

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis

2020-10-05

Abstract excerpt

<h4>Summary</h4> Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that shape negatively charged curved lipid membranes during membrane remodeling processes. The BAR domain proteins ICA69, PICK1 and arfaptins have recently been demonstrated to coordinate the budding and formation of immature secretory granules (ISGs) at the trans -Golgi network. Here, we identify four coding varian...

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Literature Corpus work: 0816a15e-0fd0-57b0-9d99-9ab29796c284
DOI: 10.1101/2020.10.05.325951

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