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Article

Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity.

PloS one - 1 Jan 2015

Xie Wenyan, Wen Hongling, Chu Fulu, Yan Shaofeng, Lin Bin, Xie Wenli, Liu Ying, Ren Guijie, Zhao Li, Song Yanyan, Sun Chengxi, Wang Zhiyu

Abstract excerpt

Human parainfluenza virus type 3 (HPIV3) can cause severe respiratory tract diseases in infants and young children, but no licensed vaccines or antiviral agents are currently available for treatment. Fusing the viral and target cell membranes is a prerequisite for its entry into host cells and is directly mediated by the fusion (F) protein. Although several domains of F are known to have important effects on...

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PMID: 26305905
DOI: 10.1371/journal.pone.0136474
PMCID: PMC4549179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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