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Article

The domain I-domain III linker plays an important role in the fusogenic conformational change of the alphavirus membrane fusion protein.

Journal of virology - 1 Jul 2011

Zheng Yan, Sánchez-San Martín Claudia, Qin Zhao-ling, Kielian Margaret

Abstract excerpt

The alphavirus Semliki Forest virus (SFV) infects cells through a low-pH-dependent membrane fusion reaction mediated by the virus fusion protein E1. Acidic pH initiates a series of E1 conformational changes that culminate in membrane fusion and include dissociation of the E1/E2 heterodimer, insertion of the E1 fusion loop into the target membrane, and refolding of E1 to a stable trimeric hairpin conformation. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21543498
DOI: 10.1128/JVI.00596-11
PMCID: PMC3126531

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