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Article

A fusion protein's weak link: functional constraints revealed by inhibitory peptide interaction with the parainfluenza fusion protein.

mBio - 13 May 2026

Crosby Maximilian, Kuhn Ariel J, Zipursky Gillian, Marcink Tara C, Stearns Kyle, Sobolik Elizabeth B, Vyshenska Dariia, Mook Jee Ching, Greninger Alexander L, Porotto Matteo, Gellman Samuel H, Moscona Anne

Abstract excerpt

Human parainfluenza viruses (HPIVs) cause significant respiratory illnesses including croup and pneumonia. HPIV infection begins with fusion of viral and host cell membranes, driven by the coordinated actions of the attachment (HN) and fusion (F) glycoproteins, which together form the fusion/entry complex. We have described fusion inhibitory peptides that are derived from the heptad repeat (HRC) domain of the F...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41979349
DOI: 10.1128/mbio.02741-25
PMCID: PMC13170234

Genes

HRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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