Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia.

doi:10.1002/gcc.22277

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Article

Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia.

Genes, chromosomes & cancer - 1 Nov 2015

Salaverria Itziar, Martín-Garcia David, López Cristina, Clot Guillem, García-Aragonés Manel, Navarro Alba, Delgado Julio, Baumann Tycho, Pinyol Magda, Martin-Guerrero Idoia, Carrió Ana, Costa Dolors, Queirós Ana C, Jayne Sandrine, Aymerich Marta, Villamor Neus, Colomer Dolors, González Marcos, López-Guillermo Armando, Campo Elías, Dyer Martin J S, Siebert Reiner, Armengol Lluís, Beà Sílvia

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a common disease with highly variable clinical course. Several recurrent chromosomal alterations are associated with prognosis and may guide risk-adapted therapy. We have developed a targeted genome-wide array to provide a robust tool for ascertaining abnormalities in CLL and to overcome limitations of the 4-marker fluorescence in situ hybridization (FISH). DNA from 180 CLL...

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PMID: 26305789
DOI: 10.1002/gcc.22277
PMCID: PMC4832286

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