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Article

Array comparative genomic hybridization analysis identifies recurrent gain of chromosome 2p25.3 involving the ACP1 and MYCN genes in chronic lymphocytic leukemia.

Clinical lymphoma, myeloma & leukemia - 1 Jun 2011

Ma Deqin, Chen Zhao, Patel Keyur P, Mishra Bal M, Yao Hui, Abruzzo Lynne V, Medeiros L Jeffrey, Wierda William, Keating Michael, Sargent Rachel, Luthra Rajyalakshmi

Abstract excerpt

Chromosomal aberrations are independent prognostic markers in chronic lymphocytic leukemia (CLL). Recent studies using genomic arrays have shown recurrent gains of the short arm of chromosome 2 (2p) in a subset of CLL. We evaluated 178 CLL cases for 2p gains using custom-designed oligonucleotide array-based comparative genomic hybridization (aCGH). A high frequency of 2p gains was observed in 53 of 178 (30%)...

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Share to Chromosomes, Human, Pair 2
Share to Comparative Genomic Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to N-Myc Proto-Oncogene Protein

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Source

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Identifiers

PMID: 22035742
DOI: 10.1016/j.clml.2011.03.031
PMCID: PMC4845643

Genes

ACP1
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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