Article
Molecular diagnostics in chronic lymphocytic leukemia – Pathogenetic and clinical implications
1 Jan 2008
Abstract excerpt
The clinical staging systems by Rai and Binet have remained the mainstay for clinical decision-making in patients with chronic lymphocytic leukemia (CLL). However, there is substantial heterogeneity of the disease within the clinical stage groups. In recent years, molecular and cellular markers have helped to predict the prognosis of CLL patients. The mutation status of the variable region of the Ig heavy chain...
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