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Article

DREAMing: a simple and ultrasensitive method for assessing intratumor epigenetic heterogeneity directly from liquid biopsies.

Nucleic acids research - 15 Dec 2015

Pisanic Thomas R, Athamanolap Pornpat, Poh Weijie, Chen Chen, Hulbert Alicia, Brock Malcolm V, Herman James G, Wang Tza-Huei

Abstract excerpt

Many cancers comprise heterogeneous populations of cells at primary and metastatic sites throughout the body. The presence or emergence of distinct subclones with drug-resistant genetic and epigenetic phenotypes within these populations can greatly complicate therapeutic intervention. Liquid biopsies of peripheral blood from cancer patients have been suggested as an ideal means of sampling intratumor genetic and...

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Identifiers

PMID: 26304549
DOI: 10.1093/nar/gkv795
PMCID: PMC4678844

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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