Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serially Quantifying TERT Rearrangement Breakpoints in ctDNA Enables Minimal Residual Disease Monitoring in Patients with Neuroblastoma

1 Jan 2025

Abstract excerpt

ABSTRACT: Telomerase is reactivated by genomic TERT rearrangements in ∼30% of diagnosed high-risk neuroblastomas. Dismal patient prognosis results if the RAS/MAPK/ALK signaling transduction network also harbors mutations. We present a liquid biopsy–based monitoring strategy for this particularly vulnerable pediatric patient subgroup for which real-time molecular diagnostic tools are limited to date. Droplet...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Neuroblastoma Research and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39760332
DOI: 10.1158/2767-9764.crc-24-0569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serially Quantifying TERT Rearrangement Breakpoints in ctDNA Enables Minimal Residual Disease Monitoring in Patients with NeuroblastomaPMID 39760332Read ↗

Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma.Semantic proximity Read ↗

Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk NeuroblastomaSemantic proximity Read ↗

Using droplet digital PCR to analyzeMYCNandALKcopy number in plasma from patients with neuroblastomaSemantic proximity Read ↗

Neuroblastoma Molecular Risk-Stratification of DNA Copy Number and ALK Genotyping via Cell-Free Circulating Tumor DNA ProfilingSemantic proximity Read ↗

Sequential genomic analysis using a multisample/multiplatform approach to better define rhabdomyosarcoma progression and relapseSemantic proximity Read ↗

Circulating cell-free tumor DNA analysis in pediatric cancersSemantic proximity Read ↗

Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk NeuroblastomaSemantic proximity Read ↗

Detection of Targetable Genetic Abnormalities in Neuroblastoma Circulating Tumour DNA.Semantic proximity Read ↗

Detecting Gene Rearrangements in Patient Populations Through a 2-Step Diagnostic Test Comprised of Rapid IHC Enrichment Followed by Sensitive Next-Generation SequencingSemantic proximity Read ↗

Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma.Semantic proximity Read ↗

TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomasSemantic proximity Read ↗

Multiplexed Droplet Digital PCR Assays for the Simultaneous Screening of Major Genetic Alterations in Tumors of the Central Nervous SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.