Article

Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancer

2023-11-02

Abstract excerpt

Genomic hypomethylation has recently been identified as a determinant of therapeutic responses to immune checkpoint blockade (ICB). However, tumor tissue is often unattainable, and tissue-based methylation profiling suffers from low tumor purity. In this study, we developed an assay named iMethyl to estimate the genomic hypomethylation status from cell-free DNA (cfDNA) as well as tissue by deep targeted sequencing...

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Literature Corpus work: a273e66d-9e9c-51e5-9624-cec7498e6c6b
DOI: 10.1101/2023.10.31.565052

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