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Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients

1 Dec 2022

Abstract excerpt

BACKGROUND: DNA methylation (5-mC) signals in cell-free DNA (cfDNA) of cancer patients represent promising biomarkers for minimally invasive tumor detection. The high abundance of cancer-associated 5-mC alterations permits parallel and highly sensitive assessment of multiple 5-mC biomarkers. Here, we performed genome-wide 5-mC profiling in the plasma of metastatic ALK-rearranged non-small cell lung cancer (NSCLC)...

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PMID: 36461127
DOI: 10.1186/s13148-022-01387-4

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