Article

Cell-free DNA methylome and fragmentome analysis for disease relapse monitoring in patients with Ewing Sarcoma

2025-04-28

Abstract excerpt

<h4>Summary</h4> Liquid biopsies and cell-free DNA (cfDNA) offer minimally invasive methods for the diagnosis and monitoring of Ewing Sarcoma (EwS). EwS have a low tumour mutational burden and their detection with plasma cfDNA is challenging. We hypothesised that analysing the cfDNA methylome and fragmentome could enhance sensitivity for detecting EwS and identifying early disease recurrence. We conducted whole-ge...

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Literature Corpus work: acf59ec3-c5a4-51e7-8d55-56b60d272bbd
DOI: 10.1101/2025.04.25.25325254

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