Analysis of Cancer Mutation Signatures in Blood by a Novel Ultra-Sensitive Assay: Monitoring of Therapy or Recurrence in Non-Metastatic Breast Cancer

Abstract excerpt

BACKGROUND: Tumor DNA has been shown to be present both in circulating tumor cells in blood and as fragments in the plasma of metastatic cancer patients. The identification of ultra-rare tumor-specific mutations in blood would be the ultimate marker to measure efficacy of cancer therapy and/or early recurrence. Herein we present a method for detecting microinsertions/deletions/indels (MIDIs) at ultra-high...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Advanced Biosensing Techniques and Applications
• Share to Cancer Genomics and Diagnostics
• Share to Lung Cancer Treatments and Mutations