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Epigenome-wide association study of alcohol use disorder in five brain regions

13 Nov 2021

Abstract excerpt

Alcohol use disorder (AUD) is closely linked to the brain regions forming the neurocircuitry of addiction. Postmortem human brain tissue enables the direct study of the molecular pathomechanisms of AUD. This study aims to identify these mechanisms by examining differential DNA-methylation between cases with severe AUD (n = 53) and controls (n = 58) using a brain-region-specific approach, in which sample sizes...

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PMID: 34775485
DOI: 10.1038/s41386-021-01228-7

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