Association of Single Nucleotide Polymorphisms in STAT3 with Hand-Foot Skin Reactions in Patients with Metastatic Renal Cell Carcinoma Treated with Multiple Tyrosine Kinase Inhibitors: A Retrospective Analysis in Japanese Patients.

doi:10.1007/s11523-015-0382-9

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Article

Association of Single Nucleotide Polymorphisms in STAT3 with Hand-Foot Skin Reactions in Patients with Metastatic Renal Cell Carcinoma Treated with Multiple Tyrosine Kinase Inhibitors: A Retrospective Analysis in Japanese Patients.

Targeted oncology - 1 Feb 2016

Yamamoto Kazuhiro, Shinomiya Kazuaki, Ioroi Takeshi, Hirata Sachi, Harada Kenichi, Suno Manabu, Nishioka Tatsuya, Kume Manabu, Makimoto Hiroo, Nakagawa Tsutomu, Hirano Takeshi, Bito Toshinori, Nishigori Chikako, Miyake Hideaki, Fujisawa Masato, Hirai Midori

Abstract excerpt

BACKGROUND: Signal transducer and activator of transcription (STAT)3 is a reported mediator of molecular-targeted drug-induced keratinocyte toxicity. AIM: Our purpose was to assess the association of single nucleotide polymorphisms (SNPs) in STAT3 with hand-foot skin reactions (HFSR) in patients with metastatic renal cell carcinoma (mRCC) treated with multiple tyrosine kinase inhibitors (mTKIs). PATIENTS AND...

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PMID: 26300443
DOI: 10.1007/s11523-015-0382-9

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STAT3

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