Article
A Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Effect of Topical Urea for Secondary Prophylaxis of Hand Foot Skin Reaction in Renal Cell Cancer Patients on Sunitinib Therapy.
Clinical genitourinary cancer - 1 Jun 2024
Naeem Syed Shariq, Gupta Pooja, Sahoo Ranjit Kumar, Kumar V L, Velpandian T, Singh Archana, Batra Atul, Pramanik Raja, Rastogi Sameer, Srivastava Saumya
Abstract excerpt
INTRODUCTION: Hand foot skin reaction (HFSR) is a common dose-limiting adverse effect of multi kinase inhibitors (MKI) whose mechanism is not fully understood, and the prophylaxis is inadequate. OBJECTIVE: In this pilot study, a double-blind, randomized placebo-controlled trial was conducted to evaluate the effect of topical urea in secondary prevention of sunitinib-induced HFSR in renal cell cancer patients....
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