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Article

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2009

van Erp Nielka P, Eechoute Karel, van der Veldt Astrid A, Haanen John B, Reyners An K L, Mathijssen Ron H J, Boven Epie, van der Straaten Tahar, Baak-Pablo Renée F, Wessels Judith A M, Guchelaar Henk-Jan, Gelderblom Hans

Abstract excerpt

PURPOSE: To identify genetic markers in the pharmacokinetic and pharmacodynamic pathways of sunitinib that predispose for development of toxicities: thrombocytopenia, leukopenia, mucosal inflammation, hand-foot syndrome, and any toxicity according to National Cancer Institute Common Toxicity Criteria higher than grade 2. PATIENTS AND METHODS: A multicenter pharmacogenetic association study was performed in 219...

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Identifiers

PMID: 19667267
DOI: 10.1200/JCO.2008.21.7679

Genes

ABCB1
ABCG2
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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