Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

doi:10.1016/j.clcc.2018.02.010

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Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Clinical colorectal cancer - 1 Jun 2018

Suenaga Mitsukuni, Schirripa Marta, Cao Shu, Zhang Wu, Yang Dongyun, Ning Yan, Cremolini Chiara, Antoniotti Carlotta, Borelli Beatrice, Mashima Tetsuo, Okazaki Satoshi, Berger Martin D, Miyamoto Yuji, Gopez Roel, Barzi Afsaneh, Lonardi Sara, Yamaguchi Toshiharu, Falcone Alfredo, Loupakis Fotios, Lenz Heinz-Josef

Abstract excerpt

BACKGROUND: The C-C motif chemokine ligand 5/C-C motif chemokine receptor 5 (CCL5/CCR5) pathway has been shown to induce endothelial progenitor cell migration, resulting in increased vascular endothelial growth factor A expression. We hypothesized that genetic polymorphisms in the CCL5/CCR5 pathway predict efficacy and toxicity in patients with metastatic colorectal cancer (mCRC) treated with regorafenib....

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Identifiers

PMID: 29606345
DOI: 10.1016/j.clcc.2018.02.010
PMCID: PMC7493703

Genes

CCL5
CCR5
CCL3
CCL4

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