Article
STAT3 polymorphism rs4796793 may be a predictive factor of tumor response to multiple tyrosine kinase inhibitors in metastatic renal cell carcinoma in Japanese population.
Medical oncology (Northwood, London, England) - 1 Mar 2016
Yamamoto Kazuhiro, Ioroi Takeshi, Kanaya Kazuya, Shinomiya Kazuaki, Komoto Shiho, Hirata Sachi, Harada Kenichi, Watanabe Aimi, Suno Manabu, Nishioka Tatsuya, Kume Manabu, Makimoto Hiroo, Nakagawa Tsutomu, Hirano Takeshi, Miyake Hideaki, Fujisawa Masato, Hirai Midori
Abstract excerpt
Signal transducer and activator of transcription (STAT) 3 is a key factor in multiple tyrosine kinase inhibitor (mTKI)-induced growth inhibition and apoptosis of renal cell carcinoma (RCC) cells. This study aimed to identify associations between single-nucleotide polymorphisms (SNPs) in the STAT3 gene and tumor response to mTKIs in patients with metastatic RCC (mRCC). Seventy-one patients with clear cell RCC...
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