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Article

Clinical effects of single nucleotide polymorphisms on drug-related genes in Japanese metastatic renal cell carcinoma patients treated with sunitinib.

Anti-cancer drugs - 1 Jan 2017

Numakura Kazuyuki, Tsuchiya Norihiko, Kagaya Hideaki, Takahashi Makoto, Tsuruta Hiroshi, Inoue Takamitsu, Narita Shintaro, Huang Mingguo, Satoh Shigeru, Niioka Takenori, Miura Masatomo, Habuchi Tomonori

Abstract excerpt

Although sunitinib is a well-established chemotherapeutic for metastatic renal cell carcinoma (mRCC), there are no robust markers that predict efficacy and toxicity. We analyzed the effect of single nucleotide polymorphisms (SNPs) in genes involved in sunitinib pharmacokinetics on clinical outcomes in Japanese patients with mRCC. We analyzed the effect of SNPs in genes involved in sunitinib pharmacokinetics on...

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Identifiers

PMID: 27564227
DOI: 10.1097/CAD.0000000000000425

Genes

ABCB1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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