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Article

Polymorphisms of FGFR Pathway-related Factors and Capecitabine-induced Hand-foot Syndrome in Japanese Patients With Colorectal Cancer.

Anticancer research - 1 Feb 2026

Yamanaka Riku, Matsumoto Natsumi, Murase Remi, Kubota Yutaro, Ishida Hiroo, Shimada Ken, Fujita Ken-Ichi

Abstract excerpt

BACKGROUND/AIM: Hand-foot syndrome (HFS) is a common adverse event associated with capecitabine. While the fibroblast growth factor receptor (FGFR) signaling pathway is involved in skin wound healing, its essential role in capecitabine-induced HFS remains unclear. We examined the association between polymorphisms in FGFR signaling pathway-related genes and capecitabine-induced HFS in patients with colorectal...

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Source

Identifiers

PMID: 41617448
DOI: 10.21873/anticanres.17991

Genes

FGFBP2
FGFR2
SPRY2

Provenance

PubMed metadata and Literature Corpus relationships.

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