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Article

Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype ( SASP ) in human fetal lung fibroblast cells

1 Mar 2017

Abstract excerpt

Cellular senescence is an important tumor-suppressive mechanism. However, acquisition of a senescence-associated secretory phenotype (SASP) in senescent cells has deleterious effects on the tissue microenvironment and, paradoxically, promotes tumor progression. In a drug screen, we identified melatonin as a novel SASP suppressor in human cells. Strikingly, melatonin blunts global SASP gene expression upon...

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PMID: 28247536
DOI: 10.1111/jpi.12405

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