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Article

MMP-2 -1575G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?

Journal of neuroimmunology - 15 Sept 2015

Gašparović Iva, Čizmarević Nada Starčević, Lovrečić Luca, Perković Olivio, Lavtar Polona, Sepčić Juraj, Jazbec Saša Šega, Kapović Miljenko, Peterlin Borut, Ristić Smiljana

Abstract excerpt

Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and MMP-9 in serum and cerebrospinal fluid of multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. Optic neuritis (ON) is a common symptom of both disorders. Here we investigated the impacts of MMP-2 -1575G/A and MMP-9 -1562 C/T gene polymorphisms on disease phenotype in 100 MS patients with ON as a first symptom and 376 MS...

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Identifiers

PMID: 26298319
DOI: 10.1016/j.jneuroim.2015.06.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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