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Article

The impact of osteopontin gene variations on multiple sclerosis development and progression.

Clinical & developmental immunology - 1 Jan 2012

Comi Cristoforo, Cappellano Giuseppe, Chiocchetti Annalisa, Orilieri Elisabetta, Buttini Sara, Ghezzi Laura, Galimberti Daniela, Guerini Franca, Barizzone Nadia, Perla Franco, Leone Maurizio, D'Alfonso Sandra, Caputo Domenico, Scarpini Elio, Cantello Roberto, Dianzani Umberto

Abstract excerpt

Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3' end are a predisposing factor for MS development and evolution. In this paper, we extended our analysis to a gene variation at the 5' end on the -156G > GG single nucleotide polymorphism (SNP) and...

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Identifiers

PMID: 23008732
DOI: 10.1155/2012/212893
PMCID: PMC3447190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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