Article
Functional MMP-9 polymorphisms modulate plasma MMP-9 levels in multiple sclerosis patients.
Journal of neuroimmunology - 15 Aug 2012
Fernandes Karla Simone da Silva, Brum Doralina Guimaraes, Palei Ana Carolina, Sandrim Valeria Cristina, Guerreiro Carlos Tostes, Tanus-Santos José Eduardo, Barreira Amilton Antunes
Abstract excerpt
We have described that MMP-9 C(-1562)T and (CA)(n) polymorphisms contribute to multiple sclerosis (MS). Here, we evaluate whether plasma MMP-9 levels are related to disease severity, drug therapy resistance and polymorphisms. For sub-study 1, 36 patients with MS and 35 controls were recruited. For sub-study 2, 88 individuals (53 patients and 35 controls) were included in a cross-sectional analysis. MS patients...
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