Article
Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis.
Journal of neuroimmunology - 15 Dec 2008
Benesová Yvonne, Vasků Anna, Stourac Pavel, Hladíková Magdalena, Beránek Michal, Kadanka Zdenek, Novotná Hana, Bednarík Josef
Abstract excerpt
We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects. A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene...
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